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Harrington–Hollingsworth experiment
The Harrington–Hollingsworth experiment was an experiment that established the autoimmune nature of the blood disorder immune thrombocytopenic purpura. It was performed in 1950 by the academic staff of Barnes-Jewish Hospital in St. Louis, Missouri.〔
==Experiment==
The experiment was undertaken in 1950 by William J. Harrington and James W. Hollingsworth, who postulated that in patients with idiopathic thrombocytopenic purpura (ITP), it was a blood factor that caused the destruction of platelets.〔 To test this hypothesis, Harrington received 500 ml of blood from a patient with ITP.〔 Within three hours, his platelets dropped to dangerously low levels and he experienced a seizure.〔 His platelet count remained extremely low for four days, finally returning to normal levels by the fifth day.〔 Bone marrow biopsy from Harrington's sternum demonstrated normal megakaryocytes, the cells necessary for platelet production.〔
Subsequently the experiment was repeated on all suitable staff members at the Barnes-Jewish Hospital. All subjects developed low platelet counts within three hours, and all recovered after a period of several days.〔
抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』
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